Pharmacokinetic studies of medicinal products in target animal species

Pharmacokinetic studies are a mandatory stage of preclinical and clinical testing required for the official registration of veterinary medicinal products and feed additives. They show exactly how the active substances and their metabolites behave in the body of the target animals and allow the tolerance and safety of the product to be assessed.

What is studied

Pharmacokinetics is a full cycle of laboratory tests that analyses the key parameters in detail:

• Absorption: the rate and extent to which the product enters the systemic circulation from the site of administration.
• Distribution: the concentration of the active substance in organs, tissues and body fluids.
• Metabolism: the biotransformation pathways of the compounds and the metabolites formed.
• Excretion: the time needed to eliminate the active substances and their metabolites.

The analytical data obtained form the basis for calculating the safe dose, dosing frequency and therapeutic index.

How we work

• Review of the documents provided and agreement on the study design.
• Development, validation and verification of analytical methods for the specific active substance or metabolite.
• The animal experiment, transport and storage of samples.
• Laboratory analysis.
• Statistical analysis of the results and preparation of reports.

Why choose us

Neurometrix has worked in clinical pharmacology and pharmacokinetics for more than 20 years. We guarantee:

• Reliable reports: all tests are performed on modern equipment in strict compliance with Good Laboratory Practice (GLP).
• Expert support: qualified specialists interpret the results correctly and prepare documents according to current EAEU requirements.
• Optimised timelines: well-established laboratory procedures prevent delays in preparing the registration dossier.

Cost

The cost of a pharmacokinetic study is calculated individually for each project. It depends on the chemical structure of the active substance, the number of sampling points, the target species and the complexity of method validation. To get a preliminary estimate, send us your technical requirements or a request by email.

How to order

To get a quote and agree on the study design, contact Neurometrix specialists by phone at +7 903 613-00-79 or send a request to info@neirometrix.ru. We prepare a commercial proposal within two business days.