Preclinical studies

Preclinical research of a medicinal product or feed additive is toxicological, pharmacological, chemical and other studies of a medicinal product or feed additive performed by applying scientific evaluation methods in order to obtain evidence of the safety, quality and effectiveness of a medicinal product.

Types of research conducted:

• Study of the general toxic properties of medicines and feed additives (acute, subchronic toxicity, chronic toxicity, local irritant effect) on laboratory animals;
• Study of the specific toxicity of the drug (reproductive toxicity, teratogenicity, embryotoxicity, etc.) on laboratory animals;
• Study of the tolerability of the drug by target animal species;
• Study of the pharmacokinetics of active substances of medicines and their metabolites in the body of target animals;
• Study of the timing of removal of residual amounts of active substances and their metabolites from the body of target animals after the course use of medicines.

Stages of research work:

• Development of research design;
• Assistance in developing a research plan;
• Formation of experimental groups of animals;
• Conducting an experiment on animals (laboratory or target, depending on the type of study);
• Conducting laboratory studies of biomaterial selected from animals;
• Analysis and processing of the received data;
• Generating a report on the completed works.